ea0099p318 | Pituitary and Neuroendocrinology | ECE2024
Hasenmajer Valeria
, Sbardella Emilia
, Sciarra Francesca
, Rizzo Flavio
, Simeoli Chiara
, Pivonello Claudia
, Pivonello Rosario
, Ceccato Filippo
, Scaroni Carla
, Arnaldi Giorgio
, Pofi Riccardo
, Cozzolino Alessia
, Minnetti Marianna
, Alunni Fegatelli Danilo
, Conia Simone
, Navigli Roberto
, Gianfrilli Daniele
, Anna Venneri Mary
, Isidori Andrea
Background: Glucocorticoids (GC) are potent entrainers of the circadian clock, however their effect on biological rhythms in human chronic exposure have been poorly studied. Endogenous hypercortisolism (Cushings Syndrome, CS) is a rare condition, in which circadian disruption is sustained by a tumorous source of GC excess, offering the unique opportunity to investigate the in vivo chronic effects of GC.Methods: In a 12-month prospective mu...